ENDOMETRIAL RECEPTIVITY ARRAY- Dr. Niveditha Kamaraj
The Endometrial Receptivity Array (ERA) plays a crucial role in assessing the health of the endometrium, a vital environment for early embryo development. Serving as a protective layer surrounding the uterus, the endometrium is instrumental for the implantation of the fertilized egg and subsequent baby development during gestation. Adequate nutrients, including proteins, glycogens, lipids, and fluids, are provided by the endometrium to support the baby’s growth. However, an excessively thin or thick endometrium may pose risks such as pregnancy loss or recurrent IVF failures. Therefore, ensuring the optimal health of the endometrium is paramount for a successful and healthy pregnancy.Experience personalized care on your fertility journey with Dr. Nivedtha Kamaraj, a leading IVF expert at Aakash Fertility Hospital in Chennai. Book your appointment today for guidance and support.
What is Endometrial Receptivity Array (ERA)?
The Endometrial Receptivity Array (ERA) is a specialized technique for assessing the readiness of the endometrium to support embryo implantation. Unlike traditional methods, such as vaginal ultrasound, the ERA provides a more precise determination of the endometrial receptivity. This molecular analysis focuses on 248 genes, offering insights into the ideal timing for embryo implantation. The ERA procedure involves a biopsy, extracting a small sample from the uterine lining to ensure a thorough assessment and enhance the chances of successful implantation during the critical 4-5 day implantation window.
Who needs ERA?
- Targeted Candidates:
- Individuals experiencing recurrent miscarriage.
- Those with a history of multiple miscarriages.
- Individuals facing multiple failures in IVF implantation.
- Diagnostic Purpose:
- The ERA is not intended to imply that a malfunctioning endometrium is the cause of the mentioned issues.
- Rather, it serves as a diagnostic tool to confirm or rule out the involvement of a dysfunctional endometrium in fertility challenges.
- Procedure Overview:
- Involves a biopsy to extract a small sample of the uterine lining.
- Molecular analysis of 248 genes to assess endometrial receptivity.
- Aims to pinpoint the optimal timing for embryo implantation.
- Personalized Treatment Plans:
- Information from the ERA assists in tailoring fertility treatment plans.
- Enhances the chances of successful embryo implantation by addressing specific endometrial receptivity issues.
- Improving Outcomes:
- Particularly beneficial for individuals with a history of recurrent pregnancy loss or unsuccessful IVF attempts.
- Allows for a more targeted and personalized approach to fertility treatment.
What happens during the ERA procedure?
The ERA procedure is generally a simple and minimally painful process that typically does not require hospitalization. Preparation usually commences around one to one and a half months before the scheduled embryo transfer, involving the administration of hormones like estrogen and progesterone to create an optimal environment.
During the procedure, a specialized instrument called a pipelle is gently introduced through the vagina at the anticipated peak of the implantation window. A small amount of tissue, obtained through a ‘scratch,’ may cause mild cramping or minor bleeding post-procedure. This tissue, containing RNA, is then transported to the laboratory for subsequent molecular examination.
Molecular analysis results typically fall into one of three categories:
- Pre-Receptive: Signifying that the endometrium is not yet prepared for implantation.
- Receptive: Indicating that the endometrium is ready for embryo implantation.
- Post-Receptive: Suggesting that the endometrium is no longer capable of supporting implantation.
This comprehensive analysis guides medical professionals in understanding the ideal timing for embryo transfer, providing valuable insights into the endometrial receptivity status.For expert advice and guidance on the ERA procedure, consult with Dr. Niveditha Kamaraj, best gynecologist in Chennai. Book your appointment today for personalized care and insights tailored to your needs.
– Aakash Fertility Centre & Hospital
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